The Kansas City Chiefs might be human after all. The AFC West team suffered its first loss of the 2020 regular season in Week 5 with the rival Las Vegas Raiders stealing a victory on the road at Arrowhead Stadium. Now they face the Buffalo Bills on Monday.

With head coach Andy Reid and quarterback Patrick Mahomes leading the way, the Chiefs should produce quite the memorable performance in Week 6 against the Buffalo Bills, a previously undefeated team that also lost for the first time this past Tuesday. Because the Bills suffered a demoralizing loss at the hands of the 4-0 Tennessee Titans, it might be too difficult for Buffalo to bounce back like Kansas City can — especially considering the fact that the Chiefs will be the Week 6 opponent.

The Chiefs should have minimal trouble with the Bills this time around as Kansas City should once again begin to trend upward with Buffalo potentially headed for a spiral downward.

Chiefs QB Patrick Mahomes will throw for more than 500 yards in Week 6

Kansas City Chiefs quarterback Patrick Mahomes has by no means played poorly thus far into the 2020-21 campaign. However, the former league MVP and reigning Super Bowl MVP is surely due for a breakout game to truly kick things into gear for the Chiefs this time around. With the Buffalo Bills fresh off of a poor defensive performance against the Tennessee Titans, one that saw the AFC East franchise allow a whopping 42 points, Mahomes and company could very well pile it on come Week 6. Not only that, but Mahomes will get the Chiefs moving in the right direction by throwing for more than 500 yards against the Bills.

Chiefs RB Clyde Edwards-Helaire will rush for more than 100 yards

The Buffalo Bills will be so preoccupied with trying to so slow down quarterback Patrick Mahomes, the team won't even have time to think about Kansas City Chiefs running back Clyde Edwards-Helaire. With Mahomes at the forefront for the Chiefs and heavily on the mind of the Bills, the rookie rusher in Edwards-Helaire will run absolutely wild against Buffalo in Week 6. Not only will Edwards-Helaire rush for more than 100 yards against the Bills, but the first-year running back will more than likely add a score or two to the stat sheet as well.

Bills QB Josh Allen will throw multiple interceptions against the Chiefs

The Tennessee Titans, and specifically veteran cornerback Malcolm Butler, were all over the Buffalo Bills and quarterback Josh Allen on Tuesday evening in Nashville. Even when Allen wasn't under pressure, the Bills signal caller still managed to make a slew of questionable decisions. With Allen's receivers not helping him in the slightest either, the Buffalo quarterback could once again find himself in a position that would require him to throw the football quite a bit against the Kansas City Chiefs. If that is ultimately the case for Allen, expect him to turn the football over multiple times in Week 6. More specifically, the Chiefs will force Allen to throw at least two interceptions this time around — which he also did in Week 5 against the Titans. Because Allen has the ability to use his legs en route to picking up chunks of yards while scrambling, such an ability also forces him into compromising situations outside the pocket, something that the Chiefs will be all over as a result of the Week 6 AFC clash.

The Chiefs will defeat the Bills by more than 20 points

Because the Kansas City Chiefs are currently coming off the team's first loss of the 2020-21 regular season, vengeance will certainly be on the mind of every player along the sideline come Week 6. With the Buffalo Bills slated to be on the unlucky end of what could quickly become a huge bounce back effort from Kansas City, the Chiefs are no doubt going to come out firing under head coach Andy Reid. There is just no way that the Chiefs lose consecutive games as Kansas City remains one of the best teams in the NFL. With the Bills reeling off a loss of their own at the hands of the undefeated Tennessee Titans, Buffalo appears primed to head in a totally different direction with consecutive losses looming as a legitimate possibility. After beginning the season with four straight wins, back-to-back losses could potentially submarine the team's season. This is part of the exquisite drama of a game in which both teams are coming off a defeat. One of them will lose two in a row, barring a tie. Even so, the Chiefs will win this one in a rout; these two teams are simply on different levels.