The Los Angeles Dodgers will open up a crucial three-game set against the Padres in San Diego on Friday night. It’s time to continue our MLB odds series and make a Dodgers-Padres prediction and pick.

This series features a potential preview of this year's National League Championship Series. The Dodgers and the Padres are currently the top-two teams in the National League and these games will be crucial in determining the order of the top-two come October.

Here’s how sportsbooks have set the opening Dodgers-Padres odds.

MLB Odds: Dodgers-Padres Odds

Los Angeles Dodgers -1.5 (+108)

San Diego Padres +1.5 (-128)

Over 8 Runs (-108)

Under 8 Runs (-112)

Why The Dodgers Could Cover The Spread

The Los Angeles Dodgers have won 10 of their last 11 games since dropping the season opener to the Colorado Rockies. The Dodgers have defended their title quite well this far, to say the least. Los Angeles is seeing all of this recent success without their top slugger Cody Bellinger. Justin Turner has led the way for the Dodgers, batting .390 with three home runs and 11 RBI. Los Angeles has four other players hitting over .300 and five others with at least two home runs on the season. Second-baseman Zach McKinstry has been a pleasant surprise for the Dodgers, currently hitting .333 with three home runs and 11 RBI.

Walker Buehler will get the ball in game one for the Dodgers. Buehler will make his third start of the season for his club. He is 1-0 with a 1.50 ERA in his first two starts. The right-hander has allowed two runs, ten hits, and no walks across 12 impressive innings of work for the Dodgers. The last time Buehler saw the Padres was in the 2020 NLDS, where he allowed two hits, one run, and struck out eight over four innings.

Why The Padres Could Cover The Spread

The San Diego Padres have seen a lot of success this far after an impressive offseason. Their first goal will be to conquer the NL West title for the first time in a long while. This will be a huge series for the Padres as they're currently looking up at the Dodgers in the division. Eric Hosmer has been the catalyst for this group, leading the way with three home runs and 11 RBI. Jake Cronenworth and Wil Myers are the only other Padres currently batting over .300. San Diego's fans will be excited to watch the emergence of Manny Machado at some point soon as he has seen uncharacteristic struggles out of the gate.

2018 first-rounder Ryan Weathers will make his first career start in the opener. Weathers made his first-ever appearance toward the back end of last season and faced the Dodgers once in the postseason. He allowed no hits, no runs, and two walks over 1.1 innings of work in the NLDS. Weathers has made three appearances out of the bullpen this season. He has a win and a save in six innings of work.

Final Dodgers-Padres Prediction & Pick

The Los Angeles Dodgers are a legitimate juggernaut in the National League. They are the hottest team in the league right now and have shown no signs of slowing down. The Dodgers don't know how to lose, especially with Walker Buehler on the bump. San Diego hitters are batting .111 lifetime against the flame-throwing right-hander. Ryan Weathers will have his hands full in his first career start as well. All of this leads to the final Dodgers – Padres prediction.

FINAL PICK: Los Angeles Dodgers ML (-145)