The Baltimore Orioles will look to avoid the three-game sweep in the series finale against the New York Yankees. It’s time to continue our MLB odds series and make an Orioles-Yankees prediction and pick. The New York Yankees will conclude their opening six-game homestand in the Bronx on Wednesday night. They have won two in a row and four of their last five games. Baltimore is looking to salvage the three-game set after losing the first two games of the series by a combined score of 14-2.

Here’s how sportsbooks have set the opening Orioles-Yankees odds.

MLB Odds: Orioles-Yankees Odds

Baltimore Orioles +1.5 (-110)

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New York Yankees -1.5 (-110)

Over 9 Runs (-110)

Under 9 Runs (-110)

Why The Orioles Could Cover The Spread

The Baltimore Orioles bats have gone ice-cold after their red-hot start against the Boston Red Sox in their opening series. Baltimore had the pleasure of running into Gerrit Cole last night. They can't beat themselves up for the performance against the big right-hander and have to come out aggressive in the finale. The Orioles have managed just two runs in this series, but now get a chance to face the fifth starter in the Yankee rotation in Jameson Taillon.

Rio Ruiz provided the minimal offense for the Baltimore Orioles in Tuesday's loss with a two-run homer in the top of the ninth inning. The Orioles went 0-for-4 with runners in scoring position. Baltimore will hope to get the offense back on track and get another great outing from their ace, John Means. Means tossed seven shutout innings and allowed just one hit in the opening day victory over the Red Sox. He has struggled at Yankee Stadium during his career though, going 1-1 with a 5.54 ERA.

Why The Yankees Could Cover The Spread

The New York Yankees have come alive after an opening day loss to the Blue Jays. They have won four of their last five games and two straight against this Orioles bunch. The Yanks got a stellar performance out of their ace Gerrit Cole once again in Tuesday night's 7-2 victory. He threw seven scoreless innings with 13 strikeouts and no walks. Cole is in Cy Young form early on with the Yankees. Behind an electric offense, Cole certainly won't lose many games.

The Yankees were led by slugger Aaron Judge in the win last night. Judge went 3-for-5 with a homer and four RBI, which was a great sight for concerned Yankee fans. Jay Bruce added a homer of his own and Giancarlo Stanton added a couple of absolute missiles for New York. The Bronx Bombers will turn to Jameson Taillon in the series finale. Taillon will make his first-ever start in pinstripes. He had a very solid Spring Training with a 1.09 ERA and 14 strikeouts over eight innings of work. Although Taillon is making his first career start against Baltimore, Orioles hitters are just .133 in 17 plate appearances against the Yankee right-hander.

Final Orioles-Yankees Prediction & Pick

The New York Yankees are off to a red-hot start in this series. They have scored seven runs in each of the first two games and have a great chance to exceed that number again tonight. This Yankee lineup is loaded with right-handed power hitters that have feasted on John means in the past. Means has a 5.54 lifetime ERA in Yankee Stadium. Jameson Taillon will neutralize this Orioles lineup in an electric Yankee debut. New York absolutely loves playing against Baltimore and will put on yet another impressive display.

FINAL PICK: New York Yankees -1.5 (-110)