The Chicago White Sox look to win the series Wednesday night against the Oakland Athletics after taking the first game in dominant fashion. It’s time to continue our MLB odds series and make a White Sox-Athletics prediction and pick.

Oakland currently stands at 74-64 and is 37-32 at home. If you put $100 on every single Athletics game so far this season, you’d be down $243 on the moneyline.

Chicago currently stands at 80-58 and is 34-34 on the road. If you put $100 on every single White Sox game so far this season, you’d be down $27 on the moneyline.

Here’s how sportsbooks have set the White Sox-Athletics odds.

MLB Odds: White Sox-Athletics Odds

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White Sox ML (+150)

Oakland Athletics ML (-163)

Over 8.5 Runs (-102)

Under 8.5 Runs (-118)

Why The White Sox Could Win This Game

There's no denying that Dallas Keuchel has been one of the worst starters in the league this season, but there is an argument to be made that the gap between starters is not as big as it appears to be.

Frankie Montas is a sinker-ball pitcher, but his ground ball rate is only 40%. For a pitcher who throws a hard sinker the majority of the time, this is an alarmingly low rate. Combine this with the fact that Montas holds a HR/FB rate of 11.7%, and White Sox fans should be confident that their lineup can elevate some baseballs for extra-base hits.

Additionally, like Keuchel, Montas' xERA adds on an extra half-run (from 3.68 to 4.07), indicating Montas has been helped out significantly by some fielding prowess. It might be wishful thinking, but it's not impossible that Chicago hangs some runs on Montas early.

Realistically, the Sox aren't getting a gem from their starter. That means Chicago will be dependent on their bats.

The good news is that the top half of this stellar Sox lineup has been swinging the bat well. New leadoff hitter Luis Robert, who has taken Tim Anderson's spot for the moment, went 7-for-15 at the dish in his last three games. Yoan Moncada is 5-for-14 in the last five, while Yasmani Grandal is 4-for-11 with three walks in the same span.

This White Sox team scores in bunches. In their last 10 games, they put 10-plus runs on the board four times. Keuchel will give up runs, but the Sox have the firepower to punch right back.

Why The Athletics Could Win This Game

After being stifled by Jimmy Lambert for the first half of Tuesday's matchup, the Athletics get to face a pitcher who has been one of the most hittable arms in baseball this year in Keuchel.

Just a look at Keuchel's numbers show how awful he has been, and the advanced stats show that he should actually be worse.

Through 27 starts, the lefty holds a 5.22 ERA and has allowed a whopping 49 walks in 139 2/3 innings of works. His adjusted numbers are even more of an eyesore: Keuchel has an xERA of 6.02.

In his last three starts, the former Astro allowed 16 earned runs in nine innings. He lasted just one inning against a handicapped Chicago Cubs offense just two starts ago. I could go on, but it's clear Keuchel is a shadow of the pitcher he once was.

On the other hand, the Athletics pitcher taking the mound has been terrific. Frankie Montas is looking to get his third straight win in this game.

The hard-throwing righty has now gone 12 straight starts without allowing more than three earned runs, pitching at least five innings in each of those starts.

Montas has been mowing down hitters, racking up 174 strikeouts in 156 2/3 innings of work. Usually, this wouldn't be a problem for the White Sox, whose best hitters display low chase rates.

However, over the last three games, the White Sox were whiffing left and right, striking out 28 times in the span.

If the Athletics jump on Keuchel early, it's tough to see how the White Sox can come back against Montas.

Final White Sox-Athletics Prediction & Pick

It's tempting to just simply fade Keuchel in this spot, but Oakland's moneyline odds are too juiced for my liking. The run line is a potential play, but what I'm most confident in is the Athletics' ability to get to Keuchel. Oakland's team total is currently set at 4.5 runs. In his last 11 starts, Keuchel allowed four or more earned runs by himself in seven of those appearances. The White Sox have a good bullpen, but they should allow at least one or two earned after using their best pitchers Tuesday to close the game. Take the team total for Oakland.

FINAL WHITE SOX-ATHLETICS PREDICTION: OAKLAND ATHLETICS TT OVER 4.5 RUNS (-110)