Tom Brady and the New England Patriots are entering their biggest game of the season in Week 16 against the Buffalo Bills. While the Patriots control their own destiny when it comes to the AFC East division race, the Bills are right behind them and can even up their records with a win on the road in Foxboro.

Needless to say, the Patriots can never be counted out with Brady and Bill Belichick leading the way. They have found ways to win Super Bowls with much more adversity than they have had this season. The pieces are all in place, but the Patriots now need to find a way to get going in all aspects of the game.

This week against a stout Buffalo defense, the Patriots need Brady to turn back the clock and have a big-time game. He has struggled at times this season, but he is still the greatest of all-time.

All of that being said, let's dive in and take a look at some bold predictions for Brady this week against the Bills.

Brady Will Rack Up 300 Yards and Three Touchdowns

Let's start this off by predicting that Brady is going to put up some massive numbers against the Bills' defense. Putting up 300 passing yards and three touchdowns against Buffalo is an impressive feat.

Brady has come through in big-time situations throughout his entire career. Most of his numbers are going to look solid, but there are more bold predictions to be made.

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He Will Throw At Least Two Interceptions

While there are going to be some major positives in Brady's stat line this week, there are going to be at least a couple of negatives as well. Buffalo is a defense capable of forcing turnovers in bunches. Brady is going to fall victim to that defense at least twice in this key matchup.

The Bills are going to do everything they can to disrupt Brady and the New England offense. Forcing turnovers is how they have made their living and that isn't going to change this week.

The Patriots Come Up Just Short In A Heartbreaking Loss

Finally, Brady and the Patriots are going to come up just short this week. Buffalo is a quality football team and they are going to come up with a massive road win over New England.

When everything is said and done, the Patriots are not going to be able to make the plays down the stretch that they need to make. Turnovers are going to be a big reason why they come up short. Buffalo will even up the team's records at 11-4 and will give themselves a chance to win the AFC East in Week 17.