San Francisco 49ers running back Christian McCaffrey left today's game against the Cleveland Browns with an oblique injury, according to Judy Battista of NFL.com.

Initially, the 49ers listed Christian McCaffrey as questionable to return with the oblique injury. He returned to the game briefly, but then left again and went to the locker room. It is the second significant injury for the 49ers today. They are without Deebo Samuel for the rest of the game against the Browns with a shoulder injury as well.

The 49ers also ruled McCaffrey out for the rest of the game against the Browns, according to Cam Inman of the East Bay Times. McCaffrey being out means they are down two of their best skill position players against one of the toughest defenses in the NFL this year.

Early on this season, the 49ers have been relatively healthy. The injury bug has impacted the team over the last several years, and there were some the team was dealing with in training camp. However, the start of the season came around and the team was pretty much healthy.

McCaffrey and Deebo Samuel being out makes things tougher on Brock Purdy, so it will be interesting to see how he fares, and how long those two players will be out. It will be worth monitoring reports after the game for any indications on how severe these injuries are.

If McCaffrey and Samuel are going to miss future games, the team will depend a lot on Brandon Aiyuk and George Kittle.