Coming off of a narrow loss to the Arizona Cardinals, the San Francisco 49ers are preparing for a Thursday Night Football matchup against the Seattle Seahawks. Heading into the matchup, Nick Bosa understands the gravity of the moment.

Their 24-23 loss dropped San Francisco to 2-3 on the season. Facing another NFC West rival, Bosa knows it's a game the 49ers can't afford to lose, via Nick Wagoner of ESPN.

“It's a lot of pressure,” Bosa said. “It's not a must-win because technically your season's over if it's a must-win, but it definitely feels like it. We're treating it that way.”

Over their past two seasons, the 49ers haven't lost more than five games during the regular season. The 2024 season hasn't resulted in the same San Francisco pace. Already halfway to that number entering Week 6, the 49ers know they need to turn things around in a hurry.

Article Continues Below
More San Francisco 49ers News
49ers news: George Kittle makes bold claim about tight end value in 2025
49ers’ George Kittle makes bold claim about tight end value in 2025Chris Spiering ·
Dec 8, 2024; Santa Clara, California, USA; San Francisco 49ers head coach Kyle Shanahan walks on the field before the start of the game against the Chicago Bears at Levi's Stadium. Mandatory Credit: Cary Edmondson-Imagn Images
49ers’ Kyle Shanahan drops ‘psycho’ take on Christian McCaffreyJaren Kawada ·
San Francisco 49ers wide receiver Brandon Aiyuk (11) walks on the field before the start of the game against the Kansas City Chiefs at Levi's Stadium.
49ers’ Brandon Aiyuk trashes San Francisco for persistent trade rumorsMiguel La Torre ·
image thumbnail
1 perfect San Francisco 49ers move to fill out roster before 2025 training campEnzo Flojo ·
image thumbnail
2 hottest 49ers takes coming out of 2025 minicampDouglas Fritz ·
San Francisco 49ers tight end George Kittle (85) works out with his teammates during an OTA at Levi's Stadium.
49ers’ George Kittle warns of ‘violence’ amid Robert Saleh returnLorenzo J Reyna ·

Nick Bosa and company are attempting to do everything in their part. The 49ers' defense ranks 10th in the NFL by allowing 307.8 yards per game. Bosa has racked up 18 tackles, six quarterback hits and three sacks. Furthermore, the edge rusher has earned a sterling 91.6 grade from Pro Football Focus.

On Thursday night, San Francisco will be facing off against a Seattle offense that ranks seventh in the league, averaging 376.2 YPG. With the Seahawks currently atop the NFC West with their 3-2 record, the 49ers would make a major move up the standings if they can earn a victory.

Normally, standings watching wouldn't be taking place in Week 6. But Bosa certainly is. He understands that with each loss the 49ers get further and further from reaching their ultimate goals. Their loss to the Cardinals was a devastating blow to their grand plans. The four-time Pro Bowler is looking to ensure that doesn't happen again on Thursday night.