The Buffalo Bills Week 10 matchup with the Denver Broncos on Monday Night Football is a crucial one for the team. This is as close to a must-win game as a team can have in the middle of the season as dropping to .500 could tank their playoff chances. With that in mind, here are a few bold Bill-Broncos predictions.

Buffalo beat the Miami Dolphins convincingly in Week 4 and they haven’t looked good since. Injuries have mounted over the course of the season, including for Josh Allen, who is dealing with a shoulder issue. Still, the Bills have looked confused and ineffective on both sides of the ball while struggling to beat the New York Giants and Washington Commanders and losing to the lowly New England Patriots among others.

The Bills Week 10 Monday Night Football opponent, the Broncos, may be heading in the other direction. Sean Payton, Russell Wilson, and the rest of the organization got embarrassed in Week 2 when the Dolphins hung 70 on them. They’ve looked much better in the last month, though, winning their last two heading into the bye and three of their last five.

Denver will be rested and ready to go on Monday night while the Bills limp into the game counting the days until their bye in Week 13. With that as the backdrop, let’s go ahead and make some bold Bills Week 10 predictions.

*Watch NFL games LIVE with fuboTV (click for free trial)*

The Bills defense continues to struggle

When head coach Sean McDermott took over as defensive coordinator for Leslie Frazier this season, it seemed like better days were in store. And for a while, they were.

At its best, the McDermott-led defense looked better than last season, with a bigger focus on stopping the run and more timely blitzes that flustered opposing quarterbacks. Unfortunately for the Bills, then Tre’Daviouos White went down. Then Matt Milano. Then DaQuan Jones, and so on and so on.

To paraphrase Rick Pitino, Shane Conlan and Nate Odomes aren’t walking through that door.

General manager Brandon Beane did his best to patch the holes, signing defensive tackle Linval Joseph and trading a third-round pick for former Green Bay Packers cornerback Rasul Douglas. Now, that money and draft capital may have been better spent on the other side of the ball, but that’s a different conversation for a different time.

On Monday night, the Bills will struggle to stop the Broncos, who are rested and will come in with a solid offensive plan after their bye week. Denver has figured some things out, especially in the run game in the last few weeks, and it won’t be a shock if they gash the Bills D.

The best Bills Mafia can hope for here is that if this is a tight game late (which is one of the bold Bills Week 10 predictions here), the defense can pull it together in the end and make one key stop to help win the game.

Josh Allen and the offense get some things together

Josh Allen, Bills

Generational quarterback Josh Allen got no help at the trade deadline, and as they usually do, McDermott’s coaching staff will be asking Allen and Stefon Diggs to basically win the game by themselves.

After a long week of chewing on yet another not-all-that-close loss to the Cincinnati Bengals, some things have hopefully changed. Offensive coordinator Ken Dorsey has heard the criticism all week, and veteran running back Latavius Murray even held a players-only meeting. Maybe that was enough to jumpstart the offense again.

The bold Bills Week 10 prediction is that it was, at least for a week.

Denver’s defense is not good this season, which will be a help to Buffalo. And after the recent struggles, Dorsey should have at least one game in him where he uses a bunch of motion, spreads the ball around, and uses Allen to run more in key spots.

If all that happened on Monday night, the Bills should be able to put up 28 points, a number the team hasn’t since their 48-point outburst in Week 4.

Bills 28, Broncos 27

The Bills are 7.5-point favorites in this game, but it doesn’t seem like a matchup that the Bills will win easily with their struggles and the Broncos advantages. So, the question becomes, can Josh Allen pull this one out?

The short answer for Bills fans is that he better.

With the final bold Bills Week 10 prediction being that Buffalo wins on a final drive, that will move their record on the season to 6-4 and likely put them (barely) back in the playoffs after this weekend’s action.

With games against the New York Jets, Philadelphia Eagles, Kansas City Chiefs, Dallas Cowboys, Los Angeles Chargers, Patriots, and Dolphins to close out the season, the Bills simply can’t afford a loss in Week 10.