The Kansas City Chiefs will be without wideout Sammy Watkins in Week 6 against the Buffalo Bills, per Adam Schefter of ESPN.

Watkins, who began his NFL career with the Bills, is expected to miss an extended period due to a right hamstring injury.

Sammy Watkins has caught 21 passes from Chiefs superstar quarterback Patrick Mahomes on the season for 222 yards and two touchdowns.

While Kansas City will sorely miss Watkins since he's an explosive playmaker, the team still has a bevy of options on offense and just added former Pro Bowler Le'Veon Bell after he was waived by the New York Jets.

Both the Chiefs and Bills are 4-1 on the season and coming off losses in Week 5. Kansas City lost to the Las Vegas Raiders at home, while Buffalo got smacked by the Tennessee Titans on the road.

The Chiefs are favored to win this game since they have the better quarterback and Mahomes hates losing two games in a row. However, KC can't overlook this Bills team, which has a deadly offense as well with Josh Allen at the controls.

All eyes in this game are going to be on Bell, though, to see how he performs in his first game with the Chiefs. The 28-year-old, who was one of the best running backs in the NFL during his time with the Pittsburgh Steelers, has to be motivated to get back to his star form since his tenure with the Jets was a disaster from start to finish.