The Indianapolis Colts feel like they are stuck in no man's land. Indianapolis is 4-5 headed into Week 10 but would need some serious changes to become an actual contender in the AFC. The Colts are dealing with both a QB controversy and injuries across the roster, including one of their best offensive players.

Colts head coach Shane Steichen said on Friday that wide receiver Michael Pittman Jr. will not play on Sunday, per The Athletic's James Boyd. Pittman Jr. has been dealing with a back injury and will miss his first game of the season on Sunday.

The Colts will have to rely on Josh Downs, Alec Pierce, and Adonai Mitchell with Pittman Jr. out of the lineup.

Pittman Jr. is having the worst statistical season since his rookie year. He has hauled in 30 receptions for 366 yards and two touchdowns through nine games. This is a huge difference from 2023 where he had 109 receptions for 1,152 yards and four touchdowns. That season was good enough to earn Pittman Jr. a three-year $71.5 million extension this offseason.

One reason for Pittman Jr.'s struggles could be the inconsistency at QB for the Colts. Second-year QB Anthony Richardson has been as streaky as ever and is currently benched for Joe Flacco. It can be difficult to get into a rhythm with your QB when they are always coming in and out of the lineup.

Can Colts get an upset victory against the Bills in Week 10?

Indianapolis Colts quarterback Joe Flacco (15) throws a pass against the Minnesota Vikings during the first quarter at U.S. Bank Stadium.
Mandatory Credit: Jeffrey Becker-Imagn Images

The Colts will play against the Bills in a crucial Week 10 matchup on Sunday.

Indianapolis needs a win badly. Unfortunately, the Bills are one of the most difficult opponents to play in the AFC. Buffalo has a diverse offense that can attack opposing defenses in several different ways. Josh Allen can run all over you or throw a bomb to a wide receiver streaking down the field. That's not to mention running back James Cook, who is having an incredible season.

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If the Colts want a chance to beat the Bills, they'll need a perfect game on both sides of the ball. Joe Flacco is still a competent NFL QB, so as long as he doesn't make too many mistakes the Colts will have a chance. Meanwhile, the Colts should play opportunistically on defense and try to force Josh Allen to make some mistakes.

However, if the Colts fall to 4-6, they may not be able to rescue their season down the stretch.

Colts vs. Bills will kick off at 1PM ET on Sunday.