The San Antonio Spurs will head down to Florida to take on the Toronto Raptors for the second time this season. It’s time to continue our NBA odds series and make a Spurs-Raptors prediction and pick.

San Antonio came away victorious in the first head-to-head meeting by a score of 119-114. The Spurs are currently riding a two-game winning streak and the Raptors are riding a two-game losing streak coming in.

Here’s how sportsbooks have set the opening Spurs-Raptors odds.

NBA Odds: Spurs-Raptors Odds

San Antonio Spurs -4 (-110)

Toronto Raptors +4 (-110)

Over 222.5 Points (-110)

Under 222.5 Points (-110)

Why The Spurs Could Cover The Spread

DeMar DeRozan, Spurs

This game has to be headlined by Spurs forward DeMar DeRozan, who will get another chance to take his old team down. DeMar was a fan favorite in Toronto and the trade a few years ago was shocking news for him and the Raptors faithful. He became far less relevant upon his arrival in San Antonio, but he has been playing quite well for the Spurs this season. DeRozan currently leads his club in scoring and assists and is definitely the catalyst for his team. He hit a big game-winner to clinch the recent win against the Dallas Mavericks.

San Antonio has been much better on the road in 2021. The Spurs are 16-7 ATS away from home on the season and 7-1 ATS in their last eight road games. They have also loved playing against the Raptors in recent history, covering in eight of their last nine games against Toronto. They are 4-1 ATS in their last five games on the road against Toronto as well. The road success stems from the added energy on the defensive end as the Spurs possess a top-10 defensive unit.

Why The Raptors Could Cover The Spread

Nick Nurse, Kyle Lowry, Pascal Siakam, Fred VanVleet, Raptors

The Toronto Raptors are reeling of late and now look like a team that has officially thrown in the towel. They've been without Kyle Lowry and Fred VanVleet for an extended period of time and have missed them dearly. Toronto has lost two straight games against Atlanta and New York coming in. This will be the second game of a back-to-back for the Raptors as well. Toronto is expected to be without Fred VanVleet, Paul Watson, and Jalen Harris tonight.

The Raptors will hope to keep this game low scoring as they've actually played solid defense on their home court this season. They are only allowing 108 points per game in their home games. It's unfortunate how their season has unfolded. This Raptor team poses an outside threat every night because of the talent that is still on this roster. If it wasn't for an injury-plagued season, who knows where this team would stand in the Eastern Conference.

Final Spurs-Raptors Prediction & Pick

The most important record to look at in this matchup is 1-11. That record belongs to the Toronto Raptors on the back end of back-to-back sets this season. That is not good. Toronto has looked sluggish and has shown an inability to close games out late. San Antonio is playing great basketball and still has something to play for. They have been much better on the road and homecourt advantage isn't a thing for a Canadian team currently playing their home games in Tampa, Florida. The Spurs will continue their recent dominance against the Toronto Raptors.

FINAL PICK: San Antonio Spurs -4 (-110)