The Phoenix Suns will face off against the Philadelphia 76ers on Wednesday as they continue their Eastern Conference road trip. It’s time to continue our NBA odds series and make a Suns-Sixers prediction and pick.

The Suns hold a record of 41-16 overall and 36-21 against the spread. Phoenix is coming off a hard-fought win over the Milwaukee Bucks.

The Sixers hold the best record in the East at 39-18 overall and 30-24-3 against the spread. Philadelphia is coming off a loss to the Golden State Warriors.

Here’s how sportsbooks have set the Suns-Sixers odds.

NBA Odds: Suns-Sixers Odds

Phoenix Suns -3.5 (-115)

Philadelphia 76ers +3.5 (-105)

Over 219.5 Points (-110)

Under 219.5 Points (-110)

Why The Suns Could Cover The Spread

The Suns hold the second-best spread record in the league and the second-best record in the West. They are adept at covering away from Phoenix, holding their own with a 16-9 ATS road record.

Monty Williams' group could get some help from the injury report, as the Sixers have Joel Embiid, Ben Simmons, Tobias Harris and Seth Curry as questionable to play.

The Sixers played their last matchup against the Warriors without Simmons and Harris, and the result wasn't pretty. They badly missed Simmons' perimeter defense and Harris' ability to spread the floor and get a bucket.

When Embiid was double-teamed, it seemed like Philly was helpless on the offensive end.

These problems will be made even more evident against a Suns team that has a much more balanced scoring attack than a one-man show of a Warriors team.

Phoenix is second in the league in field goal percentage and has multiple players who can drop 15-20 points with ease. Losing both Philly stars puts them in a serious hole.

On the defensive end, the Suns hold opponents to 108.2 points per game, which ranks fifth in the NBA. Their interior defense will be particularly important against Embiid, if he plays.

Deandre Ayton should be able to hold his own, and as long as he doesn't allow an Embiid rampage, the Suns are in good shape.

Why The Sixers Could Cover The Spread

While the Suns have a great spread record, they've been shaky of late, only going 5-5 ATS in their last 10 matchups.

The Sixers have had their own spread struggles of late, but they still hold the second-best home ATS record in the East, standing at 16-12 at the Wells Fargo Center.

The Sixers should be particularly motivated after a brutal loss to the Warriors as Stephen Curry made them a victim on his historic run.

Philadelphia hasn't lost two straight home games all year, and MVP candidate Joel Embiid should be ready to ensure that it stays that way if he suits up.

Embiid has been on an absolute tear in his last five games, averaging 33.2 points and 11.4 rebounds on 49.0% shooting. He is a rare player who can lead his team to a win nearly single-handedly with his end-to-end play.

Sixers bettors need to bank that the injury report brings good news in a potential Finals preview.

Final Suns-Sixers Prediction & Pick

The injury report is much too scary to touch as a Sixers bettor at the moment. Joel Embiid and Seth Curry joining the injury report has the line moving in the Suns' direction. You could wait a bit to get a better idea of who will play in this game, but as of now, Phoenix holds the advantage.

FINAL SCORE PREDICTION: PHX 113, PHI 107 (PHOENIX SUNS -3.5)