There is now a possibility that the Los Angeles Rams could be without wide receiver Van Jefferson for the 2022 NFC Championship Game against the San Francisco 49ers.

In his press conference on Friday, Rams head coach Sean McVay noted Jefferson will be questionable for the game due to his knee injury.

Jefferson entered the week dealing with a nagging knee injury, which saw him not feature in the Rams' walkthrough practice session on Wednesday. McVay mentioned during his press conference on Wednesday that the team opted to hold him out of practice in order to be “smart” with his injury.

Jefferson did go on to take part in the team’s scheduled practices on Thursday and Friday, although he was a limited participant in both sessions.

Even after he dropped a spot in the Rams’ wide receiver depth chart following the acquisition of veteran wideout Odell Beckham Jr., Jefferson has continued to be a keen target for quarterback Matthew Stafford as of late. The second-year receiver is just coming off of a showing in the NFC divisional round against the Tampa Bay Buccaneers where he featured in 90 percent of snaps on offense and recorded a pair of receptions for 29 receiving yards.

McVay did add earlier in the week that Jefferson “should be ok” regarding his injury. Still, if the former Florida Gators standout ends up being ruled out for the NFC title game, Ben Skowronek is slated to then be the No. 3 receiver option for Stafford behind both Kupp and Beckham. The rookie wideout has not hauled in a single reception so far in the playoffs.

The Rams will look to snap their six-game losing streak against the 49ers and advance to Super Bowl 56.