The San Francisco 49ers have a crucial Week 12 matchup with second-place NFC team Green Bay Packers on Sunday afternoon, but they will be without running back Matt Breida, who is dealing with an ankle injury, according to ESPN's Adam Schefter.

The 49ers and Packers are separated by one game, making Sunday's matchup a must-win for both organizations, and Aaron Rodgers is coming off a bye week for Green Bay, who visits San Francisco without the 24-year-old Breida. Luckily, for the Niners, star tight end George Kittle and wideout Emmanuel Sanders will be active, giving the Bay Area franchise a needed edge on the offensive end.

Kittle, the Pro-Bowl tight end, was revealed today to have played an October 31st game with a broken bone in his ankle.

Breida's ankle sprain sidelined him last week in the home win against the Arizona Cardinals. The third-year rusher has recorded 542 rushing yards on 100 carries in nine games, scoring one touchdown on the ground and one in the air

The Niners also get the 32-year-old veteran Sanders back. The ex-Broncos wideout was acquired by the deadline this season for two draft picks and has been very efficient. Sanders was previously listed as questionable this week with a rib injury, and he has tallied 194 receiving yards on 16 receptions for two touchdowns four games into his tenure with San Francisco.

The story of Sunday's matchup will likely occur with the 49ers' defense against Rodgers, however.

The Packers' high octane offense will be matched with the lethal Niners defense, which has been the backbone for success all season long.