The Indianapolis Colts have one of the best offensive line units in the NFL, but they'll be without one of their stalwart linemen for the rest of Sunday's contest. According to the NFL Network's Tim Pelissero, Anthony Castonzo has been ruled out for the rest of the game versus the Tennessee Titans with a knee injury.

It remains to be seen what the extent of Castonzo's knee injury is. But seeing that the Colts aren't giving him a chance to return, they believe it could be something that could cause him to miss some time.

Since being selected in the first round of the 2011 NFL Draft, Castonzo has been a cornerstone in the Colts' offense. The Boston College product has started in 142 games in his career, starting in 16 games in six of his 10 seasons with Indianapolis.

Following the end of the 2019 season, Castonzo considered retirement after nine years in the NFL. However, after being offered a two-year, $33 million extension, Castonzo chose to return to the Colts for at least another season.

Despite never making a Pro Bowl in his career, Castonzo has been a consistent player for Indianapolis. If he's forced to miss an extended period of time, the Colts will direly miss him as their blindside protector for Philip Rivers.

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Injuries have begun to pile up for Indianapolis in recent weeks, especially on the defensive side of the ball. Besides Anthony Castonzo, DeForest Buckner, Denico Autry, Ryan Kelly, and Bobby Okereke were all inactive on Sunday versus the Titans for the Colts.