We still have six days to go before the Indianapolis Colts face the Tennessee Titans in a pivotal matchup next Sunday, but we already know the Colts will be without a key player.

Colts head coach Frank Reich said on Monday that running back Marlon Mack, who underwent surgery to repair a fractured hand last week, will not play in Indianapolis' Week 13 clash with the Titans, per Josh Alper of Pro Football Talk.

“Head coach Frank Reich said on Monday that Mack will not play against the Titans in Week 13. It will be the second game that Mack has missed since suffering the injury in a Week 11 win over the Jaguars.”

When it rains, it pours.

Earlier on Monday, it was revealed that Indy would be placing tight end Eric Ebron on the injured reserve list, and throughout the course of the season, the Colts have dealt with a myriad of injuries, particularly on offense.

Indianapolis was able to run the ball well without Mack last Thursday, as halfbacks Jonathan Williams and Nyheim Hines combined for 155 yards on the ground while quarterback Jacoby Brissett added 20 rushing yards himself.

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However, the Colts ended up falling to the Houston Texans by a score of 20-17, dropping them a game behind the Texans for first place in the AFC South.

And in spite of the fact that Indy was able to pick up some yardage on the ground without Mack last week, it would obviously prefer to have Mack moving forward, as he has tallied 862 yards and four touchdowns while averaging 4.5 yards per carry this season.

Mack, who played his collegiate football at the University of South Florida, was originally selected by Indianapolis in the fourth round (143rd pick overall) of the 2017 NFL Draft.