Philadelphia Eagles defensive end and 2020 pro-bowler Brandon Graham was carted off to the locker room with an apparent left leg injury during the first half of his team's week 2 matchup with the San Francisco 49ers on Sunday, according to the Philadelphia Inquirer's Jeff McLane.

Graham, who McLane says is the Eagles' “emotional leader in all things,” was unable to start the second half against San Francisco. The Eagles will also be without guard Brandon Brooks, who also reportedly suffered a significant chest injury.

Graham made his first Pro Bowl at age 33, and finished second-team All-Pro back in 2016. He's played his entire career in Philadelphia after being drafted in round 1 with the no. 13 pick in the 2010 draft.

The severity of Graham's injury is still unclear, but McLane did make it a point to clarify that he was sitting up despite the ailment. Being carted off is never a good sign, but until an official injury report is released by the team, nothing is certain.

The Eagles currently trail the 49ers 7-3. Both squads came into Sunday's game having won their week 1 matchup (San Francisco took care of business against Detroit Lions, while Philly cleaned out the Atlanta Falcons).

Philly will take on the Dallas Cowboys next Monday.