Jacoby Brissett and the Indianapolis Colts are heading into their Week 12 matchup against the Houston Texans on Thursday Night Football looking to take a strong hold on the AFC South. After defeating the Jacksonville Jaguars last week and with the Texans losing to the Baltimore Ravens, the Colts are currently sitting on top of the division entering this week's head-to-head matchup.

The Colts would be in much better position, but they suffered two rough losses this season. They have fallen to the Miami Dolphins and Oakland Raiders, which were both games that they were expected to win.

All of that being said, let's dive in and take a look at three bold predictions for the Colts this week against the Texans.

3. Jonathan Williams Racks Up 130 Total Yards, Two Touchdowns

Indianapolis is without question in need of their running backs stepping up this week with Marlon Mack out due to a fractured hand. Jonathan Williams racked up 116 yards on 13 carries last week against the Jaguars and is likely going to be the workhorse back for this week.

Williams is going to step up in a big way for the Colts. When everything is said and done, he will have picked up 130 total yards and two touchdowns. That kind of performance from Williams will make the Colts' offense extremely difficult to slow down.

2. The Colts Will Sack Deshaun Watson Five Times

Deshaun Watson is without question one of the top quarterbacks in the NFL and is a top candidate for the MVP award this season as well. There is no way to completely shut him down, but the Colts must focus on simply slowing him down.

Justin Houston and the Indianapolis pass rush must find a way to get to the quarterback this week. If they can put consistent pressure on Watson, they will be able to force some uncharacteristic mistakes. Matt Eberflus will dial up the right plays and the Colts will end up with five sacks in the game.

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1. Indianapolis Pulls Off a 14-Point Victory

Finally, the Colts are going to get the job done this week. Frank Reich and company are in need of coming through with this win in order to take a step forward towards winning the division. With this win, the Colts will end up with a 7-4 record, while the Texans would drop to 6-5.

Not only will the Colts come out with the win, they are going to do so in impressive fashion. Beating the Texans by 14 points isn't an easy task and it will be a big-time statement from Indianapolis.