The Brooklyn Nets and Philadelphia 76ers will play in an Eastern Conference matchup on Friday night. It's time to continue our NBA odds series and make a Nets-76ers prediction and pick.

The Nets and 76ers come into the new season each with their own set of headaches. For the Nets, it's Kyrie Irving and his vaccination status. He is essentially barred from the team until he receives the COVID-19 vaccine, or the city of New York changes their COVID laws. For the 76ers, Ben Simmons is on strike it would appear. After showing up to camp last week, Simmons has refused to practice and how claims to have a sore back.

Here's how the bookmakers have set the Nets-76ers odds for this Friday matchup.

NBA Odds: Nets-76ers Odds

Brooklyn Nets -3  (-110), -146 ML

Philadelphia 76ers +3 (-110),  ML +124

Over 230 points (-110)

Under 230 points (-110)

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Why The Nets Can Cover The Spread

The Nets still have their best two players, Kevin Durant and James Harden. They are favorites in Philadelphia Friday night for that season. Brooklyn however lost their season opener to the Milwaukee Bucks. Durant and Harden will be eager to get a win Friday night to avoid an 0-2 start to the season, as each loss will create more questions about whether Kyrie Irving's absence is a big distraction for head coach Steve Nash and his team. Brooklyn is still always a solid bet as they have two of the best players in the game and a deep cast of role players that should continue to grow together.

Why The 76ers Can Cover The Spread

Joel Embiid is the center of the show, as usual. With Simmons on the mend, they'll lean on Embiid, Seth Curry and Tobias Harris, among others, to carry the load. Embiid had a dominant season last year, and will look to regain that form vs. Nets team that doesn't have a ton of answers for him in the paint. The Sixers are a solid bet as an underdog on their home floor. They will be motivated as a group this season to rebound from their postseason collapse vs. the Atlanta Hawks in the 2021 playoffs.

Final Nets-76ers Prediction & Pick

Home underdogs are always appealing. While the Nets are talented, the 76ers group that will be on the floor tonight has spent more time together than the guys who will suit up for Brooklyn. Take the 76ers to cover the spread on their home floor on Friday night, as Embiid could have a huge game vs. an unimpressive Nets frontline.

FINAL NETS-76ERS PREDICTION & PICK: 76ers +3 (-110)