The San Francisco 49ers open the 2023 season with a matchup against the Pittsburgh Steelers. San Francisco made it to the NFC Championship Game last season, but lost to the Philadelphia Eagles.

The 49ers will be looking to make another deep playoff run this season, with an elite roster in tow. San Francisco has one of the best defenses in football, led by reigning Defensive Player of the Year Nick Bosa. The team also has a very talented offense, one helmed by a healthy Brock Purdy after the former seventh-round pick underwent surgery on his throwing elbow in March.

While the 49ers are one of the best teams in the league, they can't take the Steelers for granted. Pittsburgh is a very well-coached team, with stars at all three levels of the field defensively. The offense has a ton of young talent that could break out this season. The Steelers also have home-field advantage, which could make this a challenging game for San Francisco.

With that said, let's move on to the 49ers' final injury report ahead of their Week 1 game against the Steelers.

49ers: Final injury report ahead of Week 1 game vs. Steelers

This is an extensive injury report for the 49ers heading into Week 1, so let's break everything down.

Jon Feliciano, C: Healthy (Illness)

Starting off on the injury report is backup offensive lineman Jon Feliciano. Feliciano had an illness, but has been cleared to play and will suit up for San Francisco in Week 1, serving as depth on the interior offensive line.

Oren Burks, LB: Healthy (Knee)

Oren Burks has been dealing with a knee injury, but is healthy for Week 1. Burks is a linebacker who could see some snaps for San Francisco in certain sets. Having him healthy gives the 49ers more depth for their defense.

Tashaun Gipson, S: Healthy (Back)

Tashaun Gipson is healthy for Week 1 despite dealing with a back injury earlier in the week. Gipson is one of the 49ers' starting safeties, and he will play a big role for their defense once again. Last season, Gipson had five interceptions, playing well at the starting safety spot. His availability in Week 1 will help them remain an elite defense.

Talanoa Hufanga, S: Healthy (Knee)

Talanoa Hufanga, the other starting safety, is healthy for Week 1 despite dealing with a knee injury. Hufanga was San Francisco's fifth-round pick in 2021, and he became a star last season, earning First Team All-Pro Honors. Hufanga is one of the best defensive players on the roster and will be an impact player against Pittsburgh in Week 1.

George Kittle, TE: Questionable (Groin)

One player in question for Week 1 is star tight end George Kittle. Kittle is one of the top tight ends in the league, but may miss Week 1 as he deals with a groin injury. Fans should continue to monitor Kittle's status as he is one of the Niners' top offensive weapons.

Jordan Mason, RB: Healthy (Foot)

Third-string running back Jordan Mason has been dealing with a foot injury, but is healthy for Week 1. Christian McCaffrey is the star running back for San Francisco and Elijah Mitchell is the second-string back. However, Mason could get some touches in Week 1 as San Francisco wants to be careful with the amount of touches McCaffrey receives early in the season. His health gives the 49ers more depth at running back in Week 1.

Ray-Ray McCloud, WR: Healthy (Wrist)

Ray-Ray McCloud is good to go for Sunday after dealing with a wrist injury. McCloud is the fourth wideout on the depth chart for San Francisco, and he could get some snaps on Sunday.

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Jake Moody, K: Healthy (Right Quadricep)

Jake Moody will play after being limited during practice Wednesday and Thursday with a right quadriceps injury. Moody is the starting kicker, which makes his health pivotal. With Moody ready to play in Week 1, the 49ers won't have to add another kicker.

George Odum, DB: Healthy (Shoulder)

Defensive back George Odum is healthy after dealing with a shoulder injury. Odum is a depth player in the secondary and will be ready to play significant snaps if someone in the defensive backfield goes down with injury.

Brock Purdy, QB: Healthy (Right Elbow)

Quarterback Brock Purdy was a full participant in practice this week as he comes back from a right elbow injury he suffered in the NFC Championship Game. Purdy had a great rookie campaign, helping the 49ers make a deep playoff run. While Purdy is far from the best player on the roster, he has helped them win games and will have a huge impact in Week 1.

Trent Williams, OT: Healthy (Rest)

Trent Williams is a star left tackle, but he is a veteran. Williams didn't have an injury and will suit up Sunday, as he only missed Wednesday's practice to get some extra rest.

Charvarius Ward, CB: Questionable (Heel)

Charvarius Ward's status is in question for Week 1. Ward is San Francisco's top cornerback, and his absence would give Pittsburgh an easier secondary to attack. Ward is dealing with an ankle injury and is questionable for Week 1, which is something to monitor as Sunday gets closer.

Nick Bosa, DE: Healthy (Rest)

Nick Bosa is healthy after missing Wednesday's practice. Bosa was never hurt, instead holding out as he worked on an extension with the 49ers. San Francisco signed Bosa to a five-year, $170 million deal, making him the highest-paid defender in league history. The reigning Defensive Player of the Year will play in Week 1 and be disruptive against the Steelers offensive line.

Final thoughts on 49ers' Week 1 injury report vs. Steelers

The 49ers injury report was extensive, but most of their players are healthy. Kittle and Ward's statuses will be crucial to follow before kickoff on Sunday.