On Wednesday, fantasy football managers got the news that had been fearing. New Orleans Saints running back Alvin Kamara has officially been ruled out for their game Thanksgiving night vs the Buffalo Bills.

It's the third straight game Kamara has missed. When he was ruled out a few weeks ago, it did not appear that it would be a multi-week absence. Yet, here we are.

Alvin Kamara has been dealing with a knee injury he sustained Week 9 vs the Atlanta Falcons. Considering the Saints have lost three straight games and now are in a battle to make the playoffs, the fact that he is being held out again means this injury is more serious than initially reported.

Mark Ingram, who the Saints acquired via trade midseason from the Houston Texans, practiced in a limited capacity Wednesday. That suggests that Ingram will be able to suit up on Thanksgiving. He is listed as questionable.

However, if Ingram is not at full strength, he might have a hard time finding running room against the Bills. Buffalo has allowed the 7th fewest fantasy points to opposing running backs this season. The Bills are coming off an embarrassing home loss to the Indianapolis Colts. So, you can expect them to be focused.

If Ingram also gets ruled out ahead of the game Thursday, Tony Jones would be next in line for touches. That would be far from ideal and you might be better off at a dart throw at Ty Johnson, Tevin Coleman or Rex Burkhead with better matchups.