The Buffalo Bills' running back Devin Singletary will be out for his fourth straight practice, according to Marcel Louis-Jacques of  ESPN.

After impressing throughout the first couple games, Singletary injured his hamstring during Week 2 in his matchup against the New York Giants. In the Bills' season opener, Singletary was able to rush for 70 yards on only four carries while also proving to be a threat catching the ball out of the backfield, totaling five receptions for 28 yards.

In his absence, the seemingly ageless Frank Gore has filled in great with two scores in the last two games. Drafted way back in 2005, Gore is still remarkably putting up numbers at 36 years old and is being exactly what Buffalo needs him to be. Behind Gore is also experienced running back T.J Yeldon, who had zero touches before Sunday's game against the Cincinnati Bengals.

Singletary joins a list of Bills that have been hampered by injury including tight end Tyler Kroft and linebacker Corey Thompson.

The Bills will undoubtedly face their toughest matchup so far this season as they will host the team that has dominated the division for more than a decade, the New England Patriots. We already know Bills mafia will be ready for more than ready for this huge matchup, the only question is how many tables will be smashed if the Bills are indeed able to pull out victory and head to 4-0 atop the division.