The Denver Broncos will head to Orchard Park, New York, to face the Buffalo Bills on Monday Night Football. We're here to share our NFL odds series, make a Broncos-Bills prediction, and pick while showing you how to watch.

The Broncos are 3-5 heading into this matchup, as they have had two weeks to prepare after stunning the Kansas City Chiefs. Now, they hope they can turn their season around. Coach Sean Payton and quarterback Russell Wilson must create a good game plan to stun the Bills at Orchard Park.

The Bills lost 24-18 to the Cincinnati Bengals in their last game. Unfortunately, they fell behind 21-7 at halftime. They battled back to draw to within one score. Sadly, they fell short as they could not tie the game. Josh Allen went 26 for 38 with 258 yards passing with one touchdown and an interception while rushing eight times for 44 yards and a score. Meanwhile, Jared Cook rushed six times for 20 yards. Stefon Diggs caught six passes for 86 yards and one touchdown. Additionally, Dalton Kincaid had 10 receptions for 81 yards.

The Bills lead the Broncos 23-16-1 in the overall series. Additionally. the Bills have won the last three in a row. They also have won three consecutive games at home against the Broncos.

Here are the Broncos-Bills NFL odds, courtesy of FanDuel. 

NFL Odds: Broncos-Bills Odds

Denver Broncos: +7 (-105)

Buffalo Bills: -7 (-115)

Over: 47.5 (-110)

Under: 47.5 (-110)

How to Watch Broncos vs. Bills Week 10

Time: 8:16 PM ET/5:16 PM PT

TV: ABC and ESPN

Stream: fuboTV (Click for free trial), NFL Sunday Ticket if out-of-market

Why The Broncos Could Cover The Spread

The Broncos have actually had a good offense this season despite the 3-5 start. While Wilson struggled last season, it has not been the case this season, as he is projected to hit over 30 touchdowns this season.

Wilson has passed for 1,613 yards, 16 touchdowns, and four interceptions. Thus, he has done a better job of protecting the ball this season. Javonte Williams has rushed 90 times for 357 yards but has not scored a touchdown yet. Meanwhile, Jaleel McLaughlin has rushed 38 times for 268 yards and a touchdown. Courtland Sutton has caught 33 passes for 380 yards and six touchdowns. Additionally, Jerry Jeudy has had 27 receptions for 336 yards and a score.

The defense has not played nearly as badly as their 70-point blunder against the Miami Dolphins in October. Yet, there is still work to do to improve upon the season if the Broncos wish to get back into the playoff race. Jonathon Cooper has 20 solo tackles and 4.5 sacks. Additionally, Nik Bonitto has 17 solo tackles and 5.5 sacks. Alex Singleton has 44 solo tackles. Overall, these three playmakers must do everything in their power to give the Broncos a fair shot in this one against a highly explosive Buffalo offense that can tear any defense apart.

The Broncos will cover the spread if they can establish the run game and keep Allen off the field. Then, they need to not allow Allen to dominate them.

Why The Bills Could Cover The Spread

The Bills have a great offense. Yet, it has not been consistent this season, and they have struggled with a 5-4 record, not looking like a Super Bowl contender at all. But they still have Allen, who can carry them on his back.

Allen has passed for 2,423 yards, with 18 touchdowns and nine interceptions, while also rushing 44 times for 233 yards and six scores. Meanwhile, Cook has rushed 108 times for 506 yards and one score. Diggs has caught 70 passes for 834 yards and seven touchdowns. Also, Gabe Davis has 31 receptions for 434 yards and five scores. But Davis did not record a single sack last weekend. Conversely, Dalton Kinkaid has caught 40 passes for 339 yards and one score.

The defense remains stout. First, there is Leonard Floyd, who has 11 solo tackles and seven sacks. Ed Oliver has tallied 17 solo tackles and five sacks. Also, A.J. Epenesa has added six solo tackles, five sacks, and one interception. Greg Rousseau has added 14 solo tackles and three sacks. Likewise, Jordan Poyer has leveled 30 solo tackles and one sack.

The Bills will cover the spread if Allen can be efficient with the ball, moving the chains while also avoiding turnovers. Then, the Bills must stop the run game and force the Broncos to pass on long third-down situations.

Final Broncos-Bills Prediction & Pick

The Bills have not looked like themselves this season. Additionally, the Broncos are on two weeks of preparation time. But the Bills are also so efficient at home. Thus, it is difficult to see the Broncos staying in this game for all four quarters.

Final Broncos-Bills Prediction & Pick: Buffalo Bills: -7 (-115)