The Chicago White Sox will meet the Cleveland Guardians as the two AL Central rivals begin a four-game series at Progressive Field on Monday. It’s time to continue our MLB odds coverage with a White Sox-Guardians prediction and pick.


The White Sox split the four-game weekend series with the Detroit Tigers. Now, they look to build momentum and surpass the Guardians in the AL Central standings. The Sox are 6-4 over the past ten games. Meanwhile, the Guardians have stumbled recently. They are 2-8 over 10 games and coming off a series where they lost two of three to the Kansas City Royals. It has not been easy at home either, as they are 4-6 in the last 10 games at Progressive Field. Overall, the Guardians are 20-17 at home. 

The Sox are 27-18 on the road entering this showdown but struggling at Progressive Field. Overall, the Guardians lead the series 4-1 but swept the three-game set against the Sox in April. The White Sox are 6-16 at Progressive Field since 2020. Furthermore, the Sox have struggled for years, going 12-26 since 2018 and 34-58 since 2012. It has not been an easy place to play for the Sox. 

Lance Lynn takes the mound for the White Sox, hoping to change his team’s fortunes in Cleveland. Lynn is 1-1 with a 5.33 ERA over five games started. He tossed five innings in his last outing, allowing five earned runs on six hits, including one home run and two hits. Overall, he is 4-3 with a 3.19 ERA in eight starts against the Guardians throughout his career. Lynn is 1-2 with a 3.32 ERA over three starts at Progressive Field in his career.

Cal Quantrill is on the hill for the Guardians, hoping to end their misery. Quantrill is 4-5 with a 3.86 ERA. He went just four innings in his last outing, allowing six runs (three earned) with one home run, two walks, and eight hits. Also, Quantrill is 0-1 with a 2.03 ERA in eight games (four starts) against the White Sox in his career. He last faced them in May, where he went 6 1/3 innings, allowing four earned runs on nine hits, including a home run. Quantrill is 3-0 with a 3.24 ERA in eight starts at Progressive Field in 2022. 

Courtesy of FanDuel, here are the White Sox-Guardians odds:

MLB odds: White Sox-Guardians Odds 

White Sox: -1.5 (+132)

Guardians: +1.5 (-160)

Over: 9 (-120)

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Under: 9 (-102)

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Why The White Sox Could Cover The Spread

The White Sox have little offense, but Jose Abreu and Luis Robert are a few of their weapons. Abreu is batting .292 with 10 home runs, 40 RBIs, and 48 runs scored. Additionally, he is scorching hot since a slow start, batting .353 with five home runs, 20 RBIs, and 26 runs scored in 38 games since May 31. Abreu has struggled against the Guardians this year, batting .111 (2 for 18). However, he has had better marks against them in his career, batting .240 with 26 home runs, 76 RBIs, and 63 runs scored over 136 games against Cleveland. 

Luis Robert is batting .287 with 10 home runs, 46 RBIs, and 44 runs scored. Robert has done well against the Guardians, batting .313 with three runs scored over four games. Also, he is batting .295 with two home runs, seven RBIs, and nine runs scored over 24 games in his career against Cleveland. The White Sox cover the spread if Lynn gives them a good outing, and Abreu and Robert can manufacture some runs. 

Why The Guardians Could Cover The Spread

The Guardians have solid playmakers in Jose Ramirez and Josh Naylor. Ramirez is batting .280 with 17 home runs, 66 RBIs, and 50 runs scored. However, he is batting .250 with one home run, five RBIs, and three runs scored over five games against the Sox this season. Ramirez is also batting .278 with 28 home runs, 81 RBIs, and 87 runs scored across 129 career games against Chicago. Additionally, he has done well against the Sox at home, batting .301 with 10 home runs, 38 RBIs, and 42 runs scored over 61 games at Progressive Field. 

Naylor is batting .280 with 11 home runs, 43 RBIs, and 25 runs scored across 56 games. Moreover, he owns the Sox this year, batting .529 (9 for 17) with three home runs, 12 RBIs, and five runs scored in four games against the White Sox. He is batting .349 with three home runs, 14 RBIs, and 12 runs scored across 17 career games against Chicago. The Guardians will cover the spread if their pitching holds up, and Ramirez and Naylor produce at the plate. 

Final White Sox-Guardians Prediction & Pick

The Sox and Guardians are alive in the playoff race, but not by much. The division title seems to be the only realistic goal as both teams trail the Minnesota Twins by five or fewer games. The Guardians have enjoyed success against the Sox because of solid pitching and timely hitting. Expect the success to continue as the Guardians cover the spread, keeping it close. 

Final White Sox-Guardians Prediction & Pick: Guardians: +1.5 (-160)