The Indianapolis Colts will try to avoid an 0-3 start when they travel to Tennessee to face the Titans. The Titans are 0-1 at home as they were smashed by the Arizona Cardinals 38-13 in Week 1 but bounced back to take out the Seattle Seahawks in Week 2. It's time to continue our NFL odds series and make a Colts-Titans prediction and pick.

Here's how the bookmakers have set the odds:

NFL Odds: Colts-Titans Odds

Colts: +5 (-104)
Titans: -5 (-116)
Over: 48 (-110)
Under: 48 (-110)

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Why the Colts Could Cover the Spread

Indianapolis is not off to the start they were expecting with Carson Wentz at the center of the offense. The team has an 0-2 record and has to travel south to play a Titans team that just upset the Seahawks in Seattle. Indy’s offense is averaging 20 points per game with three turnovers. Luckily, they are facing a Titans defense that has looked abysmal so far this season. Tennessee is giving up 35.5 points per game on 407 total yards to opponents.

The Colts have won four of their last five road games. Michael Pittman Jr. and Jack Doyle have been the main targets on offense for Wentz so far this season. These two have combined for 237 receiving yards on 19 catches. Jonathan Taylor leads the ground game with 107 yards on 32 carries.

Tennessee is only 1-4 against the spread in their last five home games and 1-4 against the spread in their last five games overall. The Colts are 5-1 against the spread in their previous six road games.

Why the Titans Could Cover the Spread

The Titans offense finally woke up in the second half of Week 2 against Seattle. After scoring just nine points on three field goals in the first half, the Titans outscored the Seahawks 21-6 to send the game into overtime.

Derrick Henry had one of his monster games, totaling 182 rush yards and three touchdowns. Henry did not find the end-zone in Week 1 against the Cardinals. Tannehill also led the comeback, throwing for 347 yards and rushing for 27 yards.

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GM Ran Carthon in the middle, Joe Alt, Adisa Isaac, Jamari Thrash around him, and Tennessee Titans wallpaper in the background

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GM Chris Ballard in the middle, Jared Verse, Troy Franklin, Jaden Hicks around him, and Indianapolis Colts wallpaper in the background

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Fortunately for the Titans, Carson Wentz is questionable for Sunday’s matchup, and Indianapolis will be forced to start Jacob Eason, a young player with just five career pass attempts. The physicality in the trenches could be too much for a Colts team that is already banged up.

In his second game, Julio Jones had a strong outing for the Titans and will feast on this vulnerable secondary along with AJ Brown.

Final Colts-Titans Prediction & Pick

If Wentz does not play, I am not sure how confident one must be to take the Colts on the road. However, Indianapolis is 4-1 against the spread in the last five meetings against Tennessee. The Colts are desperate for a win, but this game feels set up for Tennessee to come out on top. If Wentz is ruled out, I would lay the points with the Titans and bet it up to a seven-point spread.

Final Pick: Titans -5