The San Francisco 49ers are getting a healthy Trent Williams soon. Williams practiced on Wednesday and looked agile following his ankle injury.

That also means the “Achilles heel” for two NFL teams is coming back to the 49ers' blindside.

Pro Football Focus rolled out their list of “Achilles heel” players for each NFL team. The left tackle happens to be a big thorn on the side of not one, but two different NFL franchises.

“Every NFL team has that handful of opposing players whom they just can’t seem to contain. Whether it’s a rival quarterback shredding them to bits, a wide receiver they can’t lock down or a pass rusher who takes over games, certain teams are unable to solve certain opponents,” PFF wrote.

Which 2 NFL teams have 49ers' Trent Williams as ‘Achilles heel?' 

San Francisco 49ers offensive tackle Trent Williams (71) blocks against New York Jets defensive end Will McDonald IV (99) during the third quarter at Levi's Stadium.
Darren Yamashita-Imagn Images

The rival Arizona Cardinals is one team that has difficulty with Williams. And they see him twice a year. But the other is the Detroit Lions — who rarely face Williams during the regular season but past battles suggest Detroit's struggles.

Article Continues Below
More San Francisco 49ers News
San Francisco 49ers wide receiver Brandon Aiyuk (11) and quarterback Brock Purdy (13) celebrate a touchdown against the Jacksonville Jaguars during the first quarter at EverBank Stadium.
49ers Insider wonders if Brock Purdy, Brandon Aiyuk are beefingMiguel La Torre ·
Kansas City Chiefs wide receiver Chris Conley (17) against the New England Patriots during the AFC championship game at Arrowhead Stadium.
Former 49ers, Chiefs wide receiver makes retirement decisionJaren Kawada ·
49ers star Nick Bosa against the Cardinals on January 5, 2025.
49ers star Nick Bosa heaps rare praise on first-round rookieJaren Kawada ·
San Francisco 49ers head coach Kyle Shanahan against the Arizona Cardinals at State Farm Stadium.
ESPN gives 49ers, Bears, Patriots best chance of biggest turnaroundDouglas Fritz ·
San Francisco 49ers head coach Kyle Shanahan, right, confers with defensive coordinator Robert Saleh during the teamís rookie minicamp.
49ers rumors: How World Cup could cost San Francisco $37 millionJackson Stone ·
NFC defensive end Nick Bosa of the San Francisco 49ers (left) with brother and AFC linebacker Joey Bosa during the Pro Bowl Skills Challenge at Nicholson Fieldhouse
How long 49ers’ Nick Bosa thought Joey Bosa would team up with himJaren Kawada ·

PFF dove into why the Cards have difficulty with the longtime blindside protector.

‘Williams has made a habit of mauling everybody in front of him. And the Arizona Cardinals are likely awaiting the day he retires. Across nine games against the Cardinals since 2020, Williams has recorded an unreal 96.9 PFF overall grade and a 97.5 PFF run-blocking grade. Arizona certainly has its own run defense to at least partially blame, but Williams is a freight train the team just can’t stop,” PFF wrote.

Turns out the Lions are another who have a hard time countering Williams.

“He’s faced the Lions twice in the past four years. And earned at least an elite 90.0 PFF overall grade on both occasions. As is often the case with Williams, the brunt of the damage was done on the ground. He earned an incredible 92.6 PFF run-blocking grade across the two matchups,” PFF said.
Williams isn't getting any younger. He's nearing his 40s and reached a point where older players tend to wear down. General manager John Lynch shot down Williams retirement rumors three months ago, however. Williams missed action due to his ankle, including the final two games as S.F. finished 6-11.