The San Diego Padres continue their road trip when they take on the Los Angeles Angels as they look to continue their climb up the National League West standings as they look to make up ground on the Los Angeles Dodgers in this Tuesday night matchup at Angel Stadium. It is time to continue our MLB odds series with a Padres-Cubs prediction, pick, and how-to-watch.

San Diego Padres head into Game 3 of this three-game series looking to take this series from the Los Angeles Angels. The Padres were 7-3 coming into this series behind some red-hot bats at the plate however, they cooled down quite a bit in their 3-4 loss to the Royals and then a 1-2 in the series opener loss to the Angeles. They will send Dylan Cease who will be looking to rebound after an up-and-down start to his season on Wednesday night.

Los Angeles Angels have been downright dreadful prior to this series with the Padres losing seven out of their last 10 games and they are looking to finally get a series victory before the Padres leave town on Wednesday. The Angels hope when they send out flamethrowing Jose Soriano to the mound he can spark some life into this Angels pitching staff and come away with the victory on Wednesday night when they play host to the visiting San Diego Padres in this interleague matchup.

Here are the MLB Odds, courtesy of FanDuel. 

MLB Odds: Padres-Angels Odds

San Diego Padres: -1.5 (+108)

Moneyline: -154

Los Angeles Angels: +1.5 (-130)

Moneyline: +130

Over: 7.5 (-112)

Under: 7.5 (-108)

How to Watch Padres vs. Angels

Time: 9:40 PM ET/4:40 PM PT

TV: Fox Sports West, MLB Extra Innings

Stream: fuboTV (Click for free trial)

Why The Padres Will Cover The Spread/Win

The upcoming clash between the San Diego Padres and the Los Angeles Angels on Wednesday night is set to be a thrilling encounter, with Dylan Cease taking the mound for the Padres against José Soriano of the Angels.

Dylan Cease has been a standout performer this season, boasting a 5-4 record and an impressive 3.42 ERA. His ability to dominate hitters with a lethal combination of a high-90s fastball and a devastating slider has made him one of the most formidable pitchers in the league. Cease’s WHIP of 0.97 indicates his exceptional control and ability to limit baserunners, which will be crucial against an Angels lineup that has struggled to find consistency.

The Padres' offense, led by stars like Fernando Tatis Jr. and Manny Machado, has the potential to break open games with their power and speed. Despite their 13-19 road record, the Padres have shown they can produce runs in bunches, particularly against less experienced pitchers like Soriano. The Padres' lineup is well-balanced and capable of exploiting any weaknesses in Soriano’s game, which could lead to early runs and put pressure on the Angels.

José Soriano, while talented, is still finding his footing in the majors. With a 2-5 record and a 3.86 ERA in 2024, Soriano has shown promise but also vulnerability, particularly against potent lineups. The Padres' experienced hitters are likely to capitalize on any mistakes Soriano makes, especially in high-leverage situations.

The combination of Dylan Cease’s pitching prowess and the Padres' explosive offense gives San Diego a significant edge in this matchup. Cease’s ability to shut down opposing hitters and the Padres' knack for scoring runs will be key factors in their success. If Cease can maintain his dominant form and the Padres' bats come alive, they are well-positioned to secure a road victory against the Angels on Wednesday night.

Why The Angels Will Cover The Spread/Win

The upcoming matchup between the Los Angeles Angels and the San Diego Padres on Wednesday night promises to be an intriguing contest, particularly with the pitching duel between José Soriano and Dylan Cease.

José Soriano, a promising right-hander for the Angels, has shown flashes of brilliance in his young career. Despite a modest 2-5 record and a 3.86 ERA this season, Soriano has demonstrated the ability to get out of tough situations, as evidenced by his impressive strikeout rate of 9.9 K/9 innings at home. His ability to generate swings and misses will be crucial against a Padres lineup that has been inconsistent at times.

The Angels have struggled at home this season with an 8-21 record, but they have shown the ability to win key games at Angel Stadium. The team’s offense, led by veterans like TaylorWard and emerging stars such as Logan O'Hoppe, has the potential to break out at any moment.

While the Padres have a slight edge in overall team performance, the Angels have the potential to pull off an upset. Soriano’s ability to strike out batters and the Angels' offensive firepower at home could be the key factors in securing a victory. If the Angels can capitalize on Cease’s occasional lapses and provide Soriano with run support, they stand a good chance of winning this crucial matchup.

Final Padres-Angels Prediction & Pick

This should be an exciting matchup between two teams full of talent. The Padres boast one of the more potent lineups in the majors and they will give a young pitcher like Soriano a ton of issues in this contest. As long as Cease can pitch lights out and keep the ball in the ballpark they can get the job done before they leave Los Angeles on Wednesday night.

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Final Padres-Angels Prediction & Pick: San Diego Padres (-154), Under 7.5 (-108)