The 7-3 Tennessee Titans will travel to Lucas Oil Stadium in Week 12 to take on the 7-3 Indianapolis Colts in a pivotal AFC South clash. The Colts are in first place in the division since they beat the Titans back on Nov. 12 by a final score of 34-17. This is a must-win game for the Titans, who are coming off a huge win in Week 11 against the Baltimore Ravens.

The Colts, meanwhile, defeated Aaron Rodgers and the Green Bay Packers in Week 11 in overtime. While starting quarterback Philip Rivers is dealing with a toe injury, the Colts are expecting the future Hall of Famer to suit up since it's a very important game for the team and he's one of the toughest players in the NFL.

With the Colts-Titans game upon us, let's take a look at four bold predictions for the contest from a Tennessee point of view.

1. Ryan Tannehill throws 2 TDs, 1 INT

In Week 10 against the Colts, Titans quarterback Ryan Tannehill wasn't all that good. He completed just 55.6 percent of his passes for 147 yards and one touchdown pass. The Colts have one of the best defenses in the NFL and they showed off their defensive prowess on Thursday Night Football against the Titans.

As expected, though, Tannehill bounced back in Week 11 against the Ravens. He threw for 259 yards and tossed two touchdowns to lead the Titans to a 30-24 win over Baltimore on the road. Even though Derrick Henry scored the game-winning touchdown, it was Tannehill's overall performance that guided Tennessee to the win on the road.

Against the Colts in Week 12, we have Tannehill throwing two touchdown passes and one interception. Look for the former Miami Dolphins star to have a similar box score from Week 11 versus the Ravens. We can see Tannehill passing for over 250 yards and having a high completion percentage. However, odds are he'll throw one interception since the Colts' defense has 12 interceptions on the season as a unit.

2. Derrick Henry rushes for over 100 yards, scores 2 TDs

Titans superstar running back Derrick Henry rushed for 103 yards on 19 carries in Week 10 against the Colts. As everyone knows, Henry is the most bruising running back in the NFL, as it takes multiple defenders to get him to the ground.

Since Week 12 is such an important game for the Titans, look for Tennessee offensive coordinator Arthur Smith to run the ball a lot with Henry, which will set up the team's play-action passing game.

Overall on the season, Henry has carried the ball 229 times for the Titans for 1,079 yards and nine touchdowns. We have the workhorse rushing for over 100 yards in Week 12 and scoring two touchdowns on the road. In nine career games against the Colts, Henry has 686 rushing yards and three scores. His fantasy owners are likely in for a big day on Sunday.

3. A.J. Brown will play and rack up 100 yards through the air

Titans wideout A.J. Brown is dealing with a knee injury, but he's expected to play against the Colts. After all, this is a divisional game with a lot at stake for Tennessee.

We have Brown recording over 100 yards versus the Colts in Week 12. He really struggled in Week 10 against Indianapolis, as Brown only caught one ball for 21 yards on four targets. The 23-year-old had four receptions for 62 yards against the Ravens in Week 11. He also caught a touchdown pass from Tannehill.

While we can't guarantee that Brown will get into the end zone in Week 12, he should have a solid game for his fantasy owners. Brown has 36 receptions on the season for 540 yards and seven touchdowns. He's undoubtedly one of the best wide receivers in the NFL.

4. Titans defeat Colts to improve to 8-3

This Titans-Colts game is set up to be an instant classic with so much on the line for both teams. It could come down right to the wire and that would be great for NFL fans as a whole.

We have the Titans defeating the Colts in this matchup to improve to 8-3 on the season and take sole possession of first place in the AFC South standings. The players are going to be motivated to avenge their Week 10 loss on national television. The Titans, who are averaging 27.9 points per game on the season, are going to show off their passing and running game in this contest against a stout Colts defense.

Right now, everyone is talking about the Pittsburgh Steelers and Kansas City Chiefs in the AFC. The Titans want to make sure the pundits aren't forgetting about them, so this Week 12 game against the Colts should be a statement contest for Tennessee.