The Los Angeles Rams were spanked 31-10 on Thursday night by the Buffalo Bills and the offensive line struggled immensely to limit the damage. Unfortunately, they also suffered a brutal injury that may have major implications moving forward. Starting center Brian Allen, one of the key protectors for quarterback Matthew Stafford, will miss 2-4 weeks with a knee injury, per Pro Football Talk.

Allen didn't miss a single snap in the Week 1 contest and it's unclear when the injury actually occurred. Sean McVay is going to have to shift his OL around now to make up for the loss. Right guard Coleman Shelton will likely start at center as a result, while backup guard Tremayne Anchrum steps in for Shelton.

To make matters worse, the Rams also lost running back Kyren Williams, who is set to miss 6-8 weeks with a high ankle sprain. Via Gary Klein of the LA Times:

Article Continues Below
More Los Angeles Rams News
New York Jets wide receiver Davante Adams (17) runs with the ball against the Los Angeles Rams during the second quarter at MetLife Stadium. Brad Penner-Imagn Images
Rams insider pumps brakes on Davante Adams-Derrick Henry comparisonJake Faigus ·
Los Angeles Rams wide receiver Puka Nacua (17) celebrates after defeating the Minnesota Vikings during an NFC wild card game at State Farm Stadium.
Burgeoning Davante Adams, Puka Nacua relationship will have Rams fans hypedRichard Pereira ·
Sean McVay has three hidden gem players on his 2025 Rams roster
3 Los Angeles Rams hidden gems on 2025 roster you need to knowLorenzo J Reyna ·
Mystery player in the middle, Matthew Stafford and Puka Nacua around him, Rams logo in the background
1 Los Angeles Rams rookie who stood out most in 2025 minicampEnzo Flojo ·
Rams news: LA bolsters offense with ex-Vikings, Titans tackle, Davis Quessenberry
Rams bolster offense with ex-Vikings, Titans tackleChris Spiering ·
Los Angeles Rams head coach Sean McVay watches offensive drills during organized team activities at Rams Practice Facility.
What Sean McVay said about Jalen Ramsey trade at Rams OTAsBen Strauss ·

Williams suffered the injury on a kickoff return in the first quarter and never actually got the chance to showcase his talent. The rookie was a fifth-round selection by the Rams in the 2022 NFL Draft out of Notre Dame. Los Angeles certainly could've used him, too. The run offense was abysmal, generating 47 yards on the ground between Darrell Henderson and Cam Akers combined. The organization could look to go out and sign another RB in the meantime.

Both of these injuries are unfortunate for the Rams, but they'll have to make due. Next up on the schedule is the Atlanta Falcons on September 18th.