The San Francisco 49ers have had a tough season full of injuries, particularly on offense. Unfortunately, that trend appears to have continued Sunday as Deebo Samuel is the latest Pro Bowler to get hit with the injury bug.

Late in the first half with the 49ers leading 21-0 over the Tampa Bay Buccaneers, Samuel rushed up the middle and got tackled in an awkward way. He was seen rolling on the ground in pain. After a few minutes, Samuel got off the ground and attempted to hop off the field. That did not last long though as he then dove back to the ground, screaming in pain.

The 49ers would have to bring the cart out to take him to the locker room. The 49ers running back was seen crying as he exited the field.

San Francisco had already been crushed by injuries. Their stud second-year running back Elijah Mitchell missed the first two months of the season with leg injuries. Upon his return, he got hurt again and has been ruled out for the rest of the season. Last week, 49ers starting QB Jimmy Garoppolo broke his foot on the opening possession.

There were rumors that Garoppolo had an outside chance of returning deep into the playoffs. Cold water has since been poured on that notion. But no blow will be bigger than losing Deebo Samuel.

Samuel is a vocal and emotional leader for this 49ers team. He is also multi-faceted, as a premier receiver and rusher. Interestingly, there were questions this offseason whether he would return to San Francisco. He made it known he did not want to play running back as well as receiver, because of the risk of injury.

Sadly, he was hurt Sunday running the football.