The San Francisco 49ers take on the New York Giants in a Week 3 primetime clash on Thursday Night Football. One of the big storylines heading into the contest was the status of 49ers wide receiver Brandon Aiyuk, who popped up on this week's injury report after suffering a shoulder injury during his team's win over the Los Angeles Rams this past week.

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49ers: Brandon Aiyuk's injury status vs Giants

Aiyuk is officially inactive for San Francisco on Thursday night. Prior reporting indicated he was unlikely to play against the Giants.

The fact that it's a short week potentially factored into the 49ers' decision with Aiyuk, who will benefit from the extra rest he'll receive coming off of the Thursday Night Football contest.

For insight on the 49ers' Week 3 matchup against the Giants, listen below:

There were some reasons for optimism regarding Aiyuk's status, as he was able to log limited practice sessions on Tuesday and Wednesday.

However, 49ers general manager John Lynch acknowledged that the 49ers wouldn't put Aiyuk out there “if it's not in his best interest,” a sentiment that ultimately seemed to win out when it came to the 49ers' thinking on his status against the Giants.

San Francisco, coming off of a Week 1 blowout of the Pittsburgh Steelers and a Week 2 victory over the division-rival Los Angeles Rams, gets to take on a Giants team that looked lost at halftime against the Arizona Cardinals before they completed a furious comeback to earn their first win of the season.

Aiyuk, 25, has been a big part of the 49ers' success so far this season, as he has racked up 11 receptions for a team-high 172 receiving yards and two touchdowns. The strong start comes on the heels of a breakout year for Aiyuk last season, as he broke the 1000-yard receiving mark for the first time in his career.

The 49ers will lean on the likes of Deebo Samuel, George Kittle and Christian McCaffrey in the passing game with Aiyuk out.