UFC 265 is set to kick off on Saturday night. You can catch the fights on ESPN+ and purchase them via pay-per-view with an ESPN+ subscription. There is a Heavyweight matchup featuring two monsters in the cage, as Derrick Lewis is set to take on Ciryl Gane for the Interim-Heavyweight title. It’s time to continue our UFC odds series with a Derrick Lewis-Ciryl Gane prediction and pick.

Derrick Lewis is a knockout artist and if he secures a KO/TKO on Saturday night, he’ll hold the record for most knockouts in UFC history with 13. Lewis is currently on a four-fight win streak and has looked impressive in the last two years.

Ciryl Gane has taken the UFC by storm and currently holds an impressive 9-0 record. He’s a very technical fighter that has proven to be one of the best in the Heavyweight division. However, Gane is in for the biggest fight of his career at UFC 265, as he’s already being given title shots.

Here’s how the sportsbooks have set the odds for the main event.

UFC 265 odds: Derrick Lewis-Ciryl Gane odds

Derrick Lewis (+280)

Ciryl Gane (-355)

Over 3.5 rounds (+125)

Under 3.5 rounds (-155)

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How Derrick Lewis wins the fight

“The Black Beast” has become a fan favorite over the years for his ferocious knockout victories and hilarious personality. Lewis has been in the UFC since 2014. His journey through the Heavyweight rankings has been long, but he seems to be at the top of his game right now. After four impressive wins in a row, it’s safe to say that Derrick Lewis is in his prime.

To secure the Interim belt though, Lewis will have to approach the bout with caution. His opponent is a dangerous striker who takes his time in the cage. Derrick Lewis enters this fight as the underdog, but he has the knockout power to end the fight at any moment. Look for Lewis to bait his opponent as he attempts to break the UFC record for most career knockouts.

How Ciryl Gane wins the fight

“Bon Gamin” has been on a tear throughout his short career and is being given an Interim title shot after just nine carer fights. Gane is a smart fighter who uses skill and speed more so than power. We’ve seen him pick-a-part Jairzinho Rozenstruik and Alexander Volkov in his last two bouts, so we should witness a similar game plan at UFC 265.

Gane knows Lewis has that one-punch knockout power, so the strategy should be to keep his distance. His opponent is incredibly strong, so working the clinch or taking him down likely won’t be the answer. Instead, Ciryl Gane should go into this fight moving around the cage frequently and hitting his opponent with strong jabs and counter strikes. The longer this fight goes, the better for Gane.

Derrick Lewis-Ciryl Gane prediction & pick

This is a Heavyweight matchup with everything on the line. Derrick Lewis brings the power, while Ciryl Gane brings the speed. With both fighters being prominent strikers, this one should stay on the feet throughout most of the bout. Based on their tendencies, Lewis will want to end this fight quickly, while Gane would benefit from going the distance. If this goes to the judges, that likely means the fight went in Gane’s favor. However, Lewis has the knockout power to end the fight at any moment.

FINAL DERRICK LEWIS-CIRYL GANE PICK: Derrick Lewis wins by KO/TKO in Round 4